CYTOSOLNUCLEUSPLASMA MEMBRANEEXTRACELLULAR SPACE1.14.13.39STAT1αPSTAT1αN:2PCaMN:2IFNγR1N:2 IFNγR2N:2IFNγN:2IFNγR2N:2IFNγR1N:2PiNOSN:2IFNγR2N:2IFNγN:2IFNγN:2IFNγR1N:2 STAT1αPIRF1ct:mRNAIRF1ct:geneiNOSct:mRNAIRF1ct:mRNAiNOSct:geneSTAT1α iNOSct:mRNAcitrullinefumarateNONOarginino-succcinateaspartatearginieO2arginieJAK1JAK24.3.2.1iNOSIRF1JAK2CaMJAK1JAK26.3.4.5JAK1IRF1ANDAND